Collagen deposition within brain metastases is associated with leptomeningeal failure after  cavity-directed radiosurgery.

Mohammed AbdulhaleemJimmy RuizStacey O'NeillRyan T HughesShadi QasemRoy E StrowdCristina FurduiKonousuke WatabeLance D MillerWaldemar DebinskiStephen TatterLinda Metheny-BarlowJaclyn J WhiteJingyun LeeEmory R McTyreAdrian LaxtonMichael D ChanJing SuMichael H Soike

Published in: Neuro-oncology advances (2023)

The degree of trichrome staining correlated with COL1A1 and portended a higher risk of LMF in patients with resected brain metastases treated with adjuvant radiosurgery. Collagen deposition and degree of fibrosis may be able to serve as a biomarker for LMF.

Keyphrases

brain metastases
small cell lung cancer
wound healing
early stage
tissue engineering
lymph node
prognostic factors