The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity.
Catrina CropanoNicola SantoroLeif GroopChiara Dalla ManClaudio CobelliAlfonso GalderisiRomy KursaweBridget PierpontMartina GoffredoSonia CaprioPublished in: Diabetes care (2017)
The rs7903146 variant in the TCF7L2 gene increases the risk of IGT/T2D in obese adolescents by impairing β-cell function, and hepatic insulin sensitivity predicts the development of IGT/T2D over time.