Peripheral Circulating Tumor DNA Detection Predicts Poor Outcomes After Liver Resection for Metastatic Colorectal Cancer.
Raja R NarayanDebra A GoldmanMithat GonenJonathan ReichelKety H HubermanSandeep RajAgnes VialeNancy E KemenyPeter J AllenVinod P BalachandranMichael I D'AngelicaRonald P DeMatteoJeffrey A DrebinWilliam R JarnaginT Peter KinghamPublished in: Annals of surgical oncology (2019)
Peripheral blood reflects the perihepatic ctDNA signature. Disagreement between tissue and ctDNA mutations may reflect the true natural history of tumor genes or an assay limitation. Peripheral ctDNA detection before liver resection is associated with worse DSS.