Carbon-ion radiotherapy versus radiofrequency ablation as initial treatment for early-stage hepatocellular carcinoma.
Naoto FujitaNaoya KanogawaHirokazu MakishimaSadahisa OgasawaraSusumu MarutaYotaro IinoYuki ShikoHiroaki KanzakiKeisuke KorokiKazufumi KobayashiSoichiro KiyonoMasato NakamuraTakayuki KondoShingo NakamotoTetsuhiro ChibaMasaru WakatsukiEi ItobayashiMasamichi ObuYoshihiro KomaRyosaku AzemotoYohei KawasakiJun KatoHiroshi TsujiNaoya KatoPublished in: Hepatology research : the official journal of the Japan Society of Hepatology (2022)
Carbon-ion radiotherapy provided a lower cumulative intrasubsegmental recurrence rate, but a comparable cumulative local recurrence rate, stage progression-free survival, and OS compared to RFA. Thus, C-ion RT appears to be one of the effective treatment options for early-stage HCC when RFA is deemed not indicated.