Hydrogen sulfide (H 2 S), together with carbon monoxide (CO) and nitric oxide (NO), is recognized as a vital gasotransmitter. H 2 S is biosynthesized by enzymatic pathways in the skin and exerts significant physiological effects on a variety of biological processes, such as apoptosis, modulation of inflammation, cellular proliferation, and regulation of vasodilation. As a major health problem, dermatological diseases affect a large proportion of the population every day. It is urgent to design and develop effective drugs to deal with dermatological diseases. Dermatological diseases can arise from a multitude of etiologies, including neoplastic growth, infectious agents, and inflammatory processes. The abnormal metabolism of H 2 S is associated with many dermatological diseases, such as melanoma, fibrotic diseases, and psoriasis, suggesting its therapeutic potential in the treatment of these diseases. In addition, therapies based on H 2 S donors are being developed to treat some of these conditions. In the review, we discuss recent advances in the function of H 2 S in normal skin, the role of altering H 2 S metabolism in dermatological diseases, and the therapeutic potential of diverse H 2 S donors for the treatment of dermatological diseases.