Ultrasensitive and quantitative toxin measurement correlates with baseline severity, severe outcomes, and recurrence among hospitalized patients with Clostridioides difficile infection.
Carolyn D AlonsoCiarán P KellyKevin W GareyAnne J Gonzales-LunaDavid WilliamsKaitlyn DaughertyChristine CuddemiJavier A Villafuerte GálvezNicole C WhiteXinhua ChenHua XuRebecca SpragueCaitlin BarrettMark MillerAgnès FoussadierAude LantzAlice BanzNira R PollockPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
In CDI patients, ultrasensitive stool toxin detection and concentration correlated with severe baseline disease, severe CDI-attributable outcomes, and recurrence, confirming the contribution of toxin quantity to disease presentation and clinical course.
Keyphrases
- escherichia coli
- end stage renal disease
- early onset
- gold nanoparticles
- label free
- ejection fraction
- newly diagnosed
- chronic kidney disease
- quantum dots
- peritoneal dialysis
- prognostic factors
- high resolution
- drug induced
- metabolic syndrome
- case report
- patient reported outcomes
- insulin resistance
- molecularly imprinted
- patient reported
- real time pcr