Reovirus-induced cell-mediated immunity for the treatment of multiple myeloma within the resistant bone marrow niche.

Louise M E MüllerGemma MignecoGina B ScottJenny DownSancha KingBasem AskarVictoria JenningsBabatunde OyajobiKaren J ScottEmma WestChristy RalphAdel SamsonElizabeth J IlettMunitta MuthanaMatt CoffeyAlan MelcherChristopher ParrishGordon CookMichelle LawsonFiona Errington-Mais

Published in: Journal for immunotherapy of cancer (2021)

These data highlight the importance of reovirus-induced immunotherapy for targeting MM cells within the BM niche and suggest that combination with agents which boost antitumor immune responses should be a priority.

Keyphrases

bone marrow
immune response
high glucose
diabetic rats
multiple myeloma
induced apoptosis
mesenchymal stem cells
single cell
drug induced
stem cells
oxidative stress
cell therapy
machine learning
big data
deep learning
stress induced