Serum sphingolipids predict de novo hepatocellular carcinoma in hepatitis C cirrhotic patients with sustained virologic response.
Victoria Therese MückeDominique ThomasMarcus Maximilian MückeOliver WaidmannStefan ZeuzemChristoph SarrazinJosef PfeilschifterJohannes VermehrenFabian FinkelmeierGeorgios GrammatikosPublished in: Liver international : official journal of the International Association for the Study of the Liver (2019)
C24DHC, C24:1DHC and especially C16Cer were superior to AFP in early detection of AFP-positive and -negative de novo HCC development. We observed significant SL profile changes upon SVR. SLs may play a role in non-invasive HCC surveillance and hepatocarcinogenesis.