Neutrophil Extracellular Traps in Tissue and Periphery in Juvenile Dermatomyositis.

Bhargavi DuvvuriLauren M PachmanGabrielle MorganAmer M KhojahMarisa Klein-GitelmanMegan L CurranStephen DotyChristian Lood

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

We found novel mechanisms of both calcium crystal-mediated neutrophil activation and cell death in JDM pathophysiology. Targeting this pathway may reduce the frequency and extent of calcinosis, as well as prevent long-term development of comorbidities, including atherosclerosis.

Keyphrases

cell death
interstitial lung disease
cardiovascular disease
disease activity
cancer therapy
cell cycle arrest
systemic sclerosis
rheumatoid arthritis
systemic lupus erythematosus
idiopathic pulmonary fibrosis