LOW THROMBIN GENERATION IN USERS OF A CONTRACEPTIVE CONTAINING ESTETROL AND DROSPIRENONE.
Laure MorimontMaud JostUlysse GaspardJean Michel FoidartJean Michel DognéJonathan DouxfilsPublished in: The Journal of clinical endocrinology and metabolism (2022)
In conclusion, an association of 15 mg estetrol with 3 mg drospirenone does not have an impact on thrombin generation compared to ethinylestradiol-containing products which, either associated with levonorgestrel or drospirenone, are able to increase the production of procoagulant factors and decrease the production of anticoagulant ones, shifting the patient to a prothrombotic state. Ethinylestradiol-containing products thus generate prothrombotic environments contrary to estetrol which demonstrates a neutral profile on hemostasis.