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5-aza-2'-Deoxycytidine Induces a RIG-I-Related Innate Immune Response by Modulating Mitochondria Stress in Neuroblastoma.

Hung-Yu LinJiin-Haur ChuangPei-Wen WangTsu-Kung LinMin-Tsui WuWen-Ming HsuHui-Ching Chuang
Published in: Cells (2020)
This study indicates that Dac effectively induces a RIG-I-related innate immune response and apoptotic signaling primarily in SK-N-AS NB cells by hypomethylating DDX58/RIG-I promoter, elevated mtROS and increased dsRNA. Dac can potentiate the cytotoxic effects of CDDP and poly(I:C) in NB cells.
Keyphrases
  • immune response
  • induced apoptosis
  • cell cycle arrest
  • cell death
  • dendritic cells
  • signaling pathway
  • gene expression
  • endoplasmic reticulum stress
  • transcription factor
  • oxidative stress
  • drug induced
  • anti inflammatory