Input-specific localization of NMDA receptor GluN2 subunits in thalamocortical neurons.
Mackenzie A TopolskiBrian L GilmoreRabeya KhondakerJuliana A MichniakCarleigh StudtmannYang ChenGwen N WagnerAaron E Pozo-ArandaShannon FarrisSharon A SwangerPublished in: bioRxiv : the preprint server for biology (2024)
NMDAR subtypes and synaptic scaffolding proteins show preferential localization at specific inputs to thalamocortical neurons.GluN2B was preferentially localized to corticothalamic synapses, while GluN2A and GluN2C were more abundant at sensory inputs to thalamocortical neurons.Colocalization between synaptic scaffolding proteins with NMDARs was GluN2 subtype-dependent.NMDAR subsynaptic organization in thalamocortical neurons is input- and GluN2-subtype specific.
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