Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity.

Yoo KimMichael RouseIsabel González-MariscalJosephine M EganJennifer F O'Connell

Published in: Nutrition & metabolism (2019)

CUR supplementation in obese subjects may alleviate the burden imposed by HFS diets. Our data indicate administration of dietary CUR reinstates PI3K, AKT and IDE levels in obese mice. Additionally, CUR treatment preserves islet integrity by downregulation of TXNIP transcription levels. Therefore, dietary CUR may have the potential to serve as a novel therapeutic agent to address the underlying links of obesity and T2DM.

Keyphrases

pi k akt
signaling pathway
cell proliferation
weight loss
cell cycle arrest
type diabetes
metabolic syndrome
adipose tissue
glycemic control
bariatric surgery
transcription factor
weight gain
machine learning
nlrp inflammasome
obese patients
skeletal muscle
cell death
high fat diet induced