Radiomics to evaluate interlesion heterogeneity and to predict lesion response and patient outcomes using a validated signature of CD8 cells in advanced melanoma patients treated with anti-PD1 immunotherapy.
Roger SunMarvin LerousseauJade Briend-DiopEmilie RoutierSeverine RoyTheophraste HenryKanta KaRui JiangNawal TemarAlexandre CarréAdrien LavilleAnthony HamaouiPierre-Antoine LaurentAngela RouyarCharlotte RobertCaroline RobertEric DeutschPublished in: Journal for immunotherapy of cancer (2022)
These results confirm the predictive value at a lesion level of the biologically inspired CD8 radiomics score in melanoma patients treated with anti-PD1-based immunotherapy and may be interesting to assess the disease spatial heterogeneity to evaluate the patient prognosis with potential clinical implication such as tumor selection for focal ablative therapies.
Keyphrases
- single cell
- induced apoptosis
- lymph node metastasis
- cell cycle arrest
- skin cancer
- contrast enhanced
- nk cells
- case report
- magnetic resonance imaging
- computed tomography
- endoplasmic reticulum stress
- human health
- magnetic resonance
- oxidative stress
- basal cell carcinoma
- risk assessment
- cell death
- cell proliferation
- climate change