Next-generation sequencing and genotype association studies reveal the association of HLA-DRB3*02:02 with delayed hypersensitivity to penicillins.

Antonino RomanoAbderrahim OussalahCeline CheryRosa-Maria Guéant-RodriguezFrancesco GaetaJosé Antonio Cornejo-GarciaPierre RouyerThomas JosseCristobalina Mayorga Torres María José Jean-Louis Guéant

Published in: Allergy (2021)

We showed that the HLA-DRB3 locus is strongly associated with an increased risk of delayed penicillin hypersensitivity, at least in Southwestern Europe. The determination of HLA-DRB3*02:02 alleles in the risk management of severe delayed hypersensitivity to penicillins should be evaluated further in larger population samples of different origins.

Keyphrases

drug induced
early onset
copy number
gene expression
molecularly imprinted
case control
high resolution
breast cancer risk