A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice.

Tian-Ying ZhangXue-Ran GuoYang-Tao WuXiao-Zhen KangQing-Bing ZhengRuo-Yao QiBin-Bing ChenYing LanMin WeiShao-Juan WangHua-Long XiongJia-Li CaoBao-Hui ZhangXiao-Yang QiaoXiao-Fen HuangYing-Bin WangMu-Jin FangYa-Li ZhangTong ChengYi-Xin ChenQin-Jian ZhaoShao-Wei LiSheng-Xiang GePei-Jer ChenJun ZhangQuan YuanNing-Shao Xia

Published in: Gut (2019)

The novel particulate protein CR-T3-SEQ13 suppressed HBsAg effectively through induction of a humoural immune response in HBV-tolerant mice. This B cell epitope-based therapeutic vaccine may provide a novel immunotherapeutic agent against chronic HBV infection in humans.

Keyphrases

wild type
hepatitis b virus
immune response
liver failure
monoclonal antibody
dendritic cells
single cell
amino acid
protein protein
dna methylation
high fat diet induced
inflammatory response