Inhibition of Pseudomonas aeruginosa secreted virulence factors reduces lung inflammation in CF mice.
Angela SandriAlessia OrtombinaFederico BoschiEleonora CremoniniMarzia BoarettiClaudio SorioPaola MelottiGabriella BergaminiMaria LleoPublished in: Virulence (2018)
Our data support the assumption that virulence factors are involved in P. aeruginosa pro-inflammatory action in CF lungs; particularly, proteases seem to play an important role. Inhibition of virulence factors production and activity resulted in decreased lung inflammation; thus, clarithromycin and protease inhibitors potentially represent additional therapeutic therapies for P. aeruginosa-infected patients.
Keyphrases
- pseudomonas aeruginosa
- cystic fibrosis
- biofilm formation
- escherichia coli
- staphylococcus aureus
- oxidative stress
- antimicrobial resistance
- helicobacter pylori
- electronic health record
- type diabetes
- metabolic syndrome
- machine learning
- helicobacter pylori infection
- candida albicans
- big data
- high fat diet induced
- insulin resistance
- data analysis