Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation.

Yimeng ZhangYa ZhouXiaohong LiXu PanJu BaiYijin ChenZhenyang LaiQiang ChenFeng MaYong Dong

Published in: Stem cell research & therapy (2024)

ALA and ELK1 are found to regulate both human granulopoiesis and erythropoiesis via RNA spliceosome, and ALA-ELK1 signal might be the target of human leukemia therapy.

Keyphrases

endothelial cells
small molecule
induced pluripotent stem cells
stem cells
acute myeloid leukemia
bone marrow
mesenchymal stem cells
cell therapy