Non-cigarette tobacco products, aryl-hydrocarbon receptor repressor gene methylation and smoking-related health outcomes.

Christina M EckhardtPallavi BalteJack E MorrisSandeep BodduluriDavid CouperJessica FettermanNeal FreedmanDavid R JacobsLifang HouRavi KalhanYongmei LiuLaura LoehrPamela L LutseyJoseph E SchwartzWendy WhiteSachin Yende Stephanie J LondonTiffany R SanchezElizabeth C Oelsner

Published in: Thorax (2024)

Pipe and cigar smoking were independently associated with lower AHRR methylation in a multiethnic cohort of US adults. Among users of non-cigarette tobacco products, lower AHRR methylation was associated with poor respiratory health outcomes and increased mortality. AHRR methylation may identify non-cigarette tobacco users with an increased risk of adverse smoking-related health outcomes.

Keyphrases

smoking cessation
genome wide
dna methylation
emergency department
gene expression
risk factors
coronary artery disease
adverse drug