Potential Risks and Benefits of Multiple Sclerosis Immune Therapies in the COVID-19 Era: Clinical and Immunological Perspectives.
Vikram BhiseSuhayl Dhib-JalbutPublished in: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2021)
Coronavirus SARS-CoV2 has emerged as one of the greatest infectious disease health challenges in a century. Patients with multiple sclerosis (MS) have a particular vulnerability to infections through their use of immunosuppressive disease-modifying therapies (DMTs). Specific DMTs pose particular risk based on their mechanisms of action (MOA). As a result, patients require individualized approaches to starting new treatments and continuation of therapy. Additionally, vaccinations must be considered carefully, and individuals on long-term B cell-depleting therapies may have diminished immune responses to vaccination, based on preserved T cells and diminished but present antibody titers to influenza vaccines. We review the immunology behind these treatments and their impact on COVID-19, as well as the current recommendations for best practices for use of DMTs in patients with MS.
Keyphrases
- sars cov
- multiple sclerosis
- respiratory syndrome coronavirus
- coronavirus disease
- end stage renal disease
- immune response
- infectious diseases
- healthcare
- mass spectrometry
- ejection fraction
- human health
- ms ms
- chronic kidney disease
- newly diagnosed
- public health
- primary care
- climate change
- toll like receptor
- prognostic factors
- white matter
- risk assessment
- clinical practice
- mesenchymal stem cells
- bone marrow