Heat shock factor 1 suppression induces spindle abnormalities and sensitizes cells to antimitotic drugs.

Hsiao-Hui KuoZhi-Rou SuJing-Yuan ChuangLing-Huei Yih

Published in: Cell division (2021)

The increased transactivation activity of HSF1 during mitosis appears to be required for accurate assembly of mitotic spindles, thereby supporting cell viability and probably AIG. In addition, inhibition of the transactivation activity of HSF1 may enhance the mitotic errors and cell death induced by anti-mitosis drugs.

Keyphrases

heat shock
cell death
induced apoptosis
cell cycle arrest
heat stress
heat shock protein
oxidative stress
cell cycle
endoplasmic reticulum stress
signaling pathway
high resolution
patient safety
mass spectrometry
adverse drug
quality improvement
electronic health record