CT Body Composition of Sarcopenia and Sarcopenic Obesity: Predictors of Postoperative Complications and Survival in Patients with Locally Advanced Esophageal Adenocarcinoma.
Fehrenbach UliTilo WuenschPia GabrielLaura SeggerTakeru YamaguchiTimo Alexander AuerNick Lasse BeetzChristian DeneckeDino KröllJonas RaakowSebastian KnitterSascha ChopraPeter C Thuss-PatienceJohann PratschkeBernd HammMatthias BieblDominik GeiselPublished in: Cancers (2021)
CT body composition imaging biomarkers can identify high-risk patients with locally advanced esophageal cancer undergoing surgery. Sarcopenic patients have a higher risk of major complications, and patients with sarcopenic obesity are more prone to postoperative pneumonia. Sarcopenia and sarcopenic obesity are both subsequently associated with a prolonged hospitalization. Low preoperative muscle mass and its decrease during the postoperative follow-up are associated with lower DFS and OS.
Keyphrases
- body composition
- locally advanced
- insulin resistance
- metabolic syndrome
- resistance training
- weight loss
- rectal cancer
- squamous cell carcinoma
- high fat diet induced
- bone mineral density
- patients undergoing
- type diabetes
- neoadjuvant chemotherapy
- end stage renal disease
- weight gain
- skeletal muscle
- computed tomography
- chronic kidney disease
- radiation therapy
- phase ii study
- minimally invasive
- dual energy
- newly diagnosed
- image quality
- contrast enhanced
- ejection fraction
- prognostic factors
- intensive care unit
- adipose tissue
- clinical trial
- magnetic resonance
- patient reported outcomes
- magnetic resonance imaging
- positron emission tomography
- body mass index
- open label
- mass spectrometry
- high intensity