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Regioselective Formal [3+2] Cycloadditions of Urea Substrates with Activated and Unactivated Olefins for Intermolecular Olefin Aminooxygenation.

Fan WuNur-E AlomJeewani P AriyarathnaJohannes NaßWei Li
Published in: Angewandte Chemie (International ed. in English) (2019)
A new class of intermolecular olefin aminooxygenation reaction is described. This reaction utilizes the classic halonium intermediate as a regio- and stereochemical template to accomplish the selective oxyamination of both activated and unactivated alkenes. Notably, urea chemical feedstock can be directly introduced as the N and O source and a simple iodide salt can be utilized as the catalyst. This formal [3+2] cycloaddition process provides a highly modular entry to a range of useful heterocyclic products with excellent selectivity and functional-group tolerance.
Keyphrases
  • energy transfer
  • room temperature
  • ionic liquid
  • reduced graphene oxide
  • molecularly imprinted
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  • structural basis