Preliminary evidence of blunted humoral response to SARS-CoV-2 mRNA vaccine in multiple sclerosis patients treated with ocrelizumab.

Antonio GalloRocco CapuanoGiovanna DonnarummaAlvino BiseccoElena GrimaldiMiriana ConteAlessandro d'AmbrosioNicola CoppolaMassimiliano GaldieroGioacchino Tedeschi

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2021)

Humoral response to BNT162b2-mRNA-vaccine in pwMS treated with OCR was clearly blunted. Further data are urgently needed to confirm and expand these preliminary results and to develop strategies to optimize the response to SARSCoV-2 vaccines in pwMS on OCR.

Keyphrases

sars cov
immune response
multiple sclerosis
binding protein
electronic health record
big data
white matter
machine learning
coronavirus disease