CD146-mediated acquisition of stemness phenotype enhances tumour invasion and metastasis after EGFR-TKI resistance in lung cancer.

Fan ZhangJia WangXiaobo WangNan WeiHaiyang LiuXiao-Ju Zhang

Published in: The clinical respiratory journal (2019)

CD146 molecule contributes to the stemness phenotype and migration in EGFR-TKI-resistant cells. CD146 might be a potential therapeutic target for EGFR-TKI-resistant lung cancer or metastasis prevention.

Keyphrases

tyrosine kinase
epidermal growth factor receptor
small cell lung cancer
advanced non small cell lung cancer
stem cells
epithelial mesenchymal transition
nk cells
induced apoptosis
chronic myeloid leukemia
cell cycle arrest
cell death
oxidative stress
cancer stem cells
human health