[18F]FDG Positron emission tomography with whole body magnetic resonance imaging ([18F]FDG-PET/MRI) as a diagnosis tool in Schwannomatosis.
Irène Gallais SérézalS FerkalL LermanS MuléB FunalotP WolkensteinPublished in: Orphanet journal of rare diseases (2021)
Schwannomatosis is a rare autosomal dominant genetic syndrome characterized by the presence of multiple schwannomas. The main symptom is neurogenic pain. The diagnosis requires the presence of several schwannomas and whole-body [18F]FDG-PET/MRI might help detect extra schwannomas in patients when the diagnosis is uncertain. Among the 25 patients treated for Schwannomatosis in our tertiary center, three men and two women had had a [18F]FDG-PET/MRI performed, and the number of schwannomas detected by [18F]FDG-PET/MRI outnumbered the number of schwannomas suspected during the clinical examination. The majority of schwannomas exhibited a radiolabeling (median of 66.7%, range 28-93%). Our findings show that [18F]FDG-PET/MRI could prove useful when suspecting schwannomatosis to accelerate diagnosis and offer optimal care to patients.
Keyphrases
- positron emission tomography
- computed tomography
- pet ct
- pet imaging
- magnetic resonance imaging
- contrast enhanced
- end stage renal disease
- diffusion weighted imaging
- ejection fraction
- newly diagnosed
- chronic pain
- type diabetes
- neuropathic pain
- spinal cord injury
- gene expression
- pregnant women
- spinal cord
- patient reported outcomes
- quality improvement
- pulmonary embolism
- genome wide
- dna methylation
- copy number
- pain management