Chemical priming of natural killer cells with branched polyethylenimine for cancer immunotherapy.

Kyung Soon ParkHye Jin KimSeung Hee Choi Joo Dong ParkMinwook LeeDae-Keum LeeJin-Ho ChoiHye Jung JangIsaac KimHae-Yun JungKeun-Hong ParkKyung-Soon Park

Published in: Journal for immunotherapy of cancer (2022)

NK cells can be chemically primed with 25KbPEI to express potent antitumor activity as well as enhanced migration ability. Because PEI is a biocompatible and Food and Drug Administration-approved chemical for biomedical use, these results suggest a cost-effective and simple method of producing therapeutic NK cells.

Keyphrases

nk cells
drug administration
natural killer cells
drug release
anti inflammatory