A clinicopathologic study of the spectrum of systemic forms of EBV-associated T-cell lymphoproliferative disorders of childhood: A single tertiary care pediatric institution experience in North America.
Amy M CoffeyAnnisa LewisAndrea N MarcoglieseM Tarek ElghetanyJyotinder N PuniaChung-Che ChangCarl E AllenKenneth L McClainAmos S GaikwadNader El-Mallawany KimCholadda V CurryPublished in: Pediatric blood & cancer (2019)
In this large pediatric clinicopathologic study of S-EBV-T-LPD of childhood in the United States, EBV-HLH, S-EBV-TCL, and S-CAEBV show many overlapping features. Diagnosis is challenging, and overall outcome is poor using current HLH-directed therapies.