Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals.

Nina Engels-DomínguezJoost M RiphagenMaxime Van EgrooElouise A KoopsLindsay F SmegalJ Alex BeckerProkopis C ProkopiouElisenda BueichekúKenneth K KwongDorene M RentzDavid H SalatReisa A SperlingKeith A JohnsonHeidi I L Jacobs

Published in: Annals of neurology (2024)

Locus coeruleus integrity has promise as a low-cost, non-invasive screening instrument to detect early cortical tau deposition and associated clinical progression in asymptomatic, low beta-amyloid individuals. ANN NEUROL 2024.

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