Impact of Antibiotic Exposure Before Immune Checkpoint Inhibitor Treatment on Overall Survival in Older Adults With Cancer: A Population-Based Study.
Lawson EngRinku SutradharYue NiuNing LiuYing LiuYosuf KaliwalMelanie Lynn PowisGeoffrey LiuJeffrey M PeppercornPhilippe L BedardMonika K KrzyzanowskaPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
In this population-level study, exposure to antibiotics and specifically fluoroquinolones before ICI therapy was observed to be associated with worse OS among older adults with cancer. Interventions aimed at altering the gut microbiome to boost immunogenicity may help improve outcomes for patients receiving ICIs with prior antibiotic exposure.