Nonphagocytic Activation of NOX2 Is Implicated in Progressive Nonalcoholic Steatohepatitis During Aging.
Joy X JiangSarah R FishAlexey TomilovYuan LiWeiguo FanAli DehnadDavid GaeSuvarthi DasGergely MozesGregory W CharvilleJon RamseyGino CortopassiNatalie J TörökPublished in: Hepatology (Baltimore, Md.) (2020)
Accelerated fibrosis in the aged is modulated by p52Shc/NOX2. We show a pathway for direct activation of the phagocytic NOX2 in hepatocytes by p52Shc binding and activating the p47phox subunit that results in redox stress and accelerated fibrosis in the aged.