Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype.
Sarah J B SnellingSylvette BasGabor J PuskasStephanie G DakinDomizio SuvaAxel FinckhCem GabayPierre HoffmeyerAndrew J CarrAnne LübbekePublished in: PloS one (2017)
The presence of IL-17 in the synovial fluid therefore identifies a substantial subset of primary end-stage OA patients with distinct biological and clinical features. Stratification of patients on the basis of IL-17 may identify those responsive to therapeutic targeting.