Development of an Anti-canine PD-L1 Antibody and Caninized PD-L1 Mouse Model as Translational Research Tools for the Study of Immunotherapy in Humans.
Wonkyung OhAlyssa Min Jung KimDeepika DhawanPerry M KirkhamRaluca OstafeJackeline FrancoUma K AryalRobert H CarnahanValery PatsekinJ Paul RobinsonDeborah W KnappSeung-Oe LimPublished in: Cancer research communications (2023)
Our cPD-L1 antibody and unique caninized mouse model will be critical research tools to improve the efficacy of immune checkpoint blockade therapy in both dogs and humans. Furthermore, these tools will open new perspectives for immunotherapy applications in cancer as well as other autoimmune diseases that could benefit a diverse and broader patient population.