Single-Cell Analysis Reveals Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension.

Gayathri ViswanathanHélène Fradin KirshnerNour NazoSaba AliAsvin GanapathiIan CummingYonghua ZhuangIssac ChoiAnmol WarmanSusana Almeida-PetersJohn HaneyDavid CorcoranYen-Rei YuSudarshan Rajagopal

Published in: American journal of respiratory and critical care medicine (2023)

These findings suggest a model for CTEPH similar to atherosclerosis, with chronic inflammation promoted by macrophages and T cells driving vascular remodeling through smooth muscle cell modulation, and suggest new approaches for pharmacologically targeting this disease.

Keyphrases

smooth muscle
single cell
pulmonary hypertension
rna seq
cell therapy
oxidative stress
high throughput
cardiovascular disease
stem cells
atrial fibrillation
coronary artery
bone marrow