Acute stress induces long-term metabolic, functional, and structural remodeling of the heart.
Thulaciga YoganathanMailyn Pérez-LivaDaniel BalvayMorgane Le-GallAlice LallemandAnais CertainGwennhael AutretYasmine MokraniFrançois GuillonneauJohanna BruceVincent NguyenUmit GencerAlain SchmittFranck LagerThomas GuilbertPatrick BrunevalJose VilarNawal MaissaElie MousseauxThomas VielGilles RenaultNadjia KachenouraBertrand TavitianPublished in: Nature communications (2023)
Takotsubo cardiomyopathy is a stress-induced cardiovascular disease with symptoms comparable to those of an acute coronary syndrome but without coronary obstruction. Takotsubo was initially considered spontaneously reversible, but epidemiological studies revealed significant long-term morbidity and mortality, the reason for which is unknown. Here, we show in a female rodent model that a single pharmacological challenge creates a stress-induced cardiomyopathy similar to Takotsubo. The acute response involves changes in blood and tissue biomarkers and in cardiac in vivo imaging acquired with ultrasound, magnetic resonance and positron emission tomography. Longitudinal follow up using in vivo imaging, histochemistry, protein and proteomics analyses evidences a continued metabolic reprogramming of the heart towards metabolic malfunction, eventually leading to irreversible damage in cardiac function and structure. The results combat the supposed reversibility of Takotsubo, point to dysregulation of glucose metabolic pathways as a main cause of long-term cardiac disease and support early therapeutic management of Takotsubo.
Keyphrases
- stress induced
- positron emission tomography
- heart failure
- magnetic resonance
- acute coronary syndrome
- cardiovascular disease
- computed tomography
- liver failure
- high resolution
- left ventricular
- magnetic resonance imaging
- respiratory failure
- coronary artery disease
- mass spectrometry
- coronary artery
- type diabetes
- oxidative stress
- single cell
- aortic dissection
- metabolic syndrome
- pet ct
- amino acid
- atrial fibrillation
- skeletal muscle
- contrast enhanced
- adipose tissue
- aortic valve
- case control
- transcatheter aortic valve replacement
- heat stress