Disinfection By-Products in Drinking Water and Bladder Cancer: Evaluation of Risk Modification by Common Genetic Polymorphisms in Two Case-Control Studies.
Laura E Beane-FreemanManolis KogevinasKenneth P CantorCristina M VillanuevaLudmila Prokunina-OlssonOscar Florez-VargasJonine D FigueroaMary H WardStella KoutrosDalsu BarisMontserrat Garcia-ClosasMolly SchwennAllison JohnsonConsol SerraAdonina TardónReina Garcia-ClosasAlfredo CarratoNuria MalatsMargaret R KaragasNathaniel RothmanDebra T SilvermanPublished in: Environmental health perspectives (2022)
We found novel suggestive evidence for a multiplicative interaction between a putative bladder carcinogen, TTHMs, and genotypes of rs907611. Given the ubiquitous exposure to THMs, further work is needed to replicate and extend this finding and to understand potential molecular mechanisms. https://doi.org/10.1289/EHP9895.