High burden of COVID-19-associated pulmonary aspergillosis (CAPA) in severely immunocompromised patients requiring mechanical ventilation.

Simon FeysKatrien LagrouHanne Moon LauwersKoen HaenenCato JacobsMarius BrusselmansYves DebaveyeGreet HermansMartin HoeniglJohan MaertensPhilippe MeerssemanMarijke PeetermansIsabel SprietChristophe VandenbrieleLore VanderbekeRobin VosEric Van WijngaerdenAlexander WilmerJoost Wauters

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)

Presence of EORTC/MSGERC host factors for invasive mold disease is associated with increased CAPA incidence and worse outcome parameters, and is the main driver for the significantly higher incidence of CAPA in the vaccination era. Our findings warrant investigation of antifungal prophylaxis in critically ill COVID-19 patients.

Keyphrases

mechanical ventilation
sars cov
end stage renal disease
risk factors
acute respiratory distress syndrome
coronavirus disease
chronic kidney disease
ejection fraction
newly diagnosed
intensive care unit
pulmonary hypertension
peritoneal dialysis
prognostic factors
candida albicans
patient reported outcomes