Early effects of androgen deprivation on bone and mineral homeostasis in adult men: a prospective cohort study.

Rougin KhalilLeen AntonioMichaël R LaurentKarel DavidNa Ri KimPieter EvenepoelAnton EisenhauerAlexander HeuserEtienne CavalierSundeep KhoslaFrank ClaessensDirk VanderschuerenBrigitte Decallonne

Published in: European journal of endocrinology (2020)

In adult men, calcium release from the skeleton occurs early following sex steroid deprivation, reflecting early bone resorption. The increase of sclerostin and reduction of bone formation markers, without changes in resorption markers, suggests a dominant negative effect on bone formation in the acute phase.

Keyphrases

bone loss
bone mineral density
soft tissue
body composition
postmenopausal women