Methylphenidate in children with monogenic obesity due to LEPR or MC4R deficiency improves feeling of satiety and reduces BMI-SDS-A case series.

Stephanie BrandtJulia von SchnurbeinBelinda LennerzKatja KohlsdorfHeike VollbachChristian DenzerHarald BodeJohannes HebebrandMartin Wabitsch

Published in: Pediatric obesity (2019)

The observed decrease in BMI trajectories with MPH use for one year is clinically meaningful in this group of patients, since the natural course would have been associated with a pronounced increase in BMI, leading to comorbidities and complications over time.

Keyphrases

body mass index
weight gain
end stage renal disease
ejection fraction
newly diagnosed
metabolic syndrome
attention deficit hyperactivity disorder
young adults
depressive symptoms
weight loss
prognostic factors
physical activity
patient reported outcomes
adipose tissue
working memory