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Immunoglobulins and Lymphocyte Subsets in Children with Infantile Tremor Syndrome.

Amanpreet KaurHimanshi ChaudharyAmit RawatJitendra Kumar SahuPrateek BhatiaSavita VermaNaveen Sankhyan
Published in: Indian journal of pediatrics (2021)
In this hospital-based, cross-sectional study, immunoglobulin levels and lymphocyte subsets status were evaluated in children with infantile tremor syndrome (ITS) [neurocutaneous infantile B12 deficiency (NIB) syndrome]. Blood samples were drawn at the baseline (n = 28) and at 6 wk (n = 25) after treatment. A low IgG/IgA or IgM was more likely in untreated children than post-treatment (p = 0.0368). Low B cells were observed in 9 (36%), low T cells in 5 (20%), and low NK cells in 2 patients. T cell subset analysis showed low CD4 + helper T cells in 5 (20%) and low CD8 + cytotoxic T cells in 2 patients. Abnormally low percentage of low B cell/T cells/NK cells was more likely in untreated children than post-treatment (p = 0.0165). In conclusion, a proportion of children with ITS have changes in immunoglobulin and T cell subsets not consistent with any clearly defined immune abnormality, and not all such changes revert at 6 wk.
Keyphrases
  • nk cells
  • young adults
  • end stage renal disease
  • peripheral blood
  • ejection fraction
  • chronic kidney disease
  • newly diagnosed
  • case report
  • prognostic factors
  • immune response
  • combination therapy