PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations.
Kellsye P FabianMichelle R PadgetRenee N DonahueKristen SolocinskiYvette RobbinsClint T AllenJohn H LeeShahrooz RabizadehPatrick Soon-ShiongJeffrey SchlomJames W HodgePublished in: Journal for immunotherapy of cancer (2021)
These studies demonstrate the antitumor efficacy of PD-L1 t-haNK cells and provide a rationale for the potential use of these cells in clinical studies.