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PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations.

Kellsye P FabianMichelle R PadgetRenee N DonahueKristen SolocinskiYvette RobbinsClint T AllenJohn H LeeShahrooz RabizadehPatrick Soon-ShiongJeffrey SchlomJames W Hodge
Published in: Journal for immunotherapy of cancer (2021)
These studies demonstrate the antitumor efficacy of PD-L1 t-haNK cells and provide a rationale for the potential use of these cells in clinical studies.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • clinical trial
  • signaling pathway