pH-sensitive nanoparticles of enhanced epigallocatechin-3-gallate in colorectal cancer therapy.
Sankha BhattacharyaPreeti Chidambar SangaveSateesh BelemkarMd Meraj AnjumPublished in: Nanomedicine (London, England) (2024)
Aim: Encapsulating epigallocatechin-3-gallate (EGCG) in pH-sensitive polymeric nanoparticles for targeted delivery of drugs could revolutionize colorectal cancer treatment. Materials & methods: Nanoparticles were synthesized to release drugs at colon pH. Dynamic light scattering measured their average diameter and ζ-potential, while differential scanning calorimetry and x-ray diffraction assessed EGCG encapsulation. Results: The nanoparticles showed stability and bioavailability in the gastrointestinal tract, efficiently encapsulating and releasing over 93% of EGCG at pH 7.2. They enhanced cytotoxicity against HT-29 cells and demonstrated antibacterial properties, increasing apoptosis and cell cycle arrest. Conclusion: The study underscores the potential of nanoparticles in enhancing EGCG delivery for colorectal cancer therapy, aiming to minimize side effects and improve therapeutic outcomes.
Keyphrases
- cell cycle arrest
- cell death
- cancer therapy
- pi k akt
- walled carbon nanotubes
- endoplasmic reticulum stress
- adipose tissue
- induced apoptosis
- type diabetes
- skeletal muscle
- mesenchymal stem cells
- magnetic resonance
- weight loss
- insulin resistance
- computed tomography
- anti inflammatory
- drug release
- smoking cessation
- contrast enhanced