Pleiotropic Effects of Isoflavones in Inflammation and Chronic Degenerative Diseases.
Jurga BernatonieneJurga Andreja KazlauskaiteDalia Marija KopustinskienePublished in: International journal of molecular sciences (2021)
Isoflavones are phytoestrogens of plant origin, mostly found in the members of the Fabaceae family, that exert beneficial effects in various degenerative disorders. Having high similarity to 17-β-estradiol, isoflavones can bind estrogen receptors, scavenge reactive oxygen species, activate various cellular signal transduction pathways and modulate growth and transcription factors, activities of enzymes, cytokines, and genes regulating cell proliferation and apoptosis. Due to their pleiotropic activities isoflavones might be considered as a natural alternative for the treatment of estrogen decrease-related conditions during menopause. This review will focus on the effects of isoflavones on inflammation and chronic degenerative diseases including cancer, metabolic, cardiovascular, neurodegenerative diseases, rheumatoid arthritis and adverse postmenopausal symptoms.
Keyphrases
- oxidative stress
- rheumatoid arthritis
- cell proliferation
- reactive oxygen species
- estrogen receptor
- transcription factor
- papillary thyroid
- emergency department
- genome wide
- endoplasmic reticulum stress
- postmenopausal women
- young adults
- gene expression
- systemic lupus erythematosus
- interstitial lung disease
- depressive symptoms
- genome wide identification
- dna binding
- systemic sclerosis
- replacement therapy