Immuno-epigenomic analysis identifies attenuated interferon responses in naïve CD4 T cells of adolescents with peanut and multi-food allergy.
Samira ImranMelanie R NeelandStephen PengAmanda VlahosDavid J MartinoShyamali Chandrika DharmageMimi L K TangSusan SawyerThanh D DangVicki L McWilliamRachel Louise PetersJennifer J KoplinKirsten P PerrettBoris NovakovicRichard SafferyPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2022)
We find that attenuated nCD4T cell responses from adolescents with food allergy are associated with specific epigenetic variation, including disruption of interferon responses, indicating dysregulation of key immune pathways that may contribute to a persistent FA phenotype. However, we recognize the small sample size, and the consequent restraint on reporting adjusted p-value statistics as limitations of the study. Further study is required to validate these findings.