Rizatriptan benzoate-loaded dissolving microneedle patch for management of acute migraine therapy.
Chao ZhongXiufeng ZhangYanfang SunZhong ShenYanan MaoTianqi LiuRui WangLei NieAmin ShavandiKhaydar E YunusovGuohua JiangPublished in: Journal of biomaterials applications (2024)
In this study, dissolving microneedles (MNs) using polyvinyl alcohol (PVA) and poly (1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VA)) as matrix materials were developed for transdermal delivery of rizatriptan benzoate (RB) for acute migraine treatment. In-vitro permeation studies were conducted to assess the feasibility of the as-fabricated dissolving MNs to release RB. Drug skin penetration were tested by Franz diffusion cells, showing an increase of the transdermal flux compared to passive diffusion due to the as-fabricated dissolving MNs having a sufficient mechanical strength to penetrate the skin and form microchannels. The pharmacological study in vivo showed that RB-loaded dissolving MNs significantly alleviated migraine-related response by up-regulating the level of 5-hydroxytryptamine (5-HT) and down-regulating the levels of calcitonin gene-related peptide (CGRP) and substance P (SP). In conclusion, the RB-loaded dissolving MNs have advantages of safety, convenience, and high efficacy over conventional administrations, laying a foundation for the transdermal drug delivery system treatment for acute migraine.
Keyphrases
- liver failure
- drug delivery
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- drug induced
- respiratory failure
- cancer therapy
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- emergency department
- soft tissue
- stem cells
- cell death
- mesenchymal stem cells
- signaling pathway
- copy number
- dna methylation
- hepatitis b virus
- replacement therapy
- smoking cessation
- cell cycle arrest
- electronic health record
- case control