PLA2G6-associated late-onset parkinsonism in a Sudanese family.

Yousuf Hasan Yousuf BakhitChristelle TessonMohamed O IbrahimKhalid EltomIsra EltaziLiena E O ElsayedSuzanne LesageOsheik SeidiJean-Christophe CorvolUllrich Wüllnernull null

Published in: Annals of clinical and translational neurology (2023)

This is the first case in which PLA2G6 is associated with late-onset parkinsonism. Functional analysis is needed to confirm the dual effect of both variants on the structure and function of iPLA2β.

Keyphrases

late onset
early onset
parkinson disease
drug induced
copy number
gene expression
dna methylation
deep brain stimulation
genome wide
data analysis