Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease.

Deepak A KajiZhijia TanGemma L JohnsonWesley HuangKaetlin VasquezJessica A LehoczkyBenjamin LeviKathryn S E CheahAlice H Huang

Published in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society (2019)

In this review, we highlight themes from a recent workshop focused on "Plasticity of Cell Fate in Musculoskeletal Tissues" held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plasticity during normal musculoskeletal development, regeneration, and disease. A thorough understanding of the biology underpinning mesenchymal cell plasticity may offer a roadmap for promoting regeneration while attenuating pathologic differentiation. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:708-718, 2020.

Keyphrases

stem cells
cell therapy
cell fate
single cell
bone marrow
gene expression
neoadjuvant chemotherapy
squamous cell carcinoma
mesenchymal stem cells
locally advanced