Transcriptional Evaluation of the Ductus Arteriosus at the Single-Cell Level Uncovers a Requirement for Vim (Vimentin) for Complete Closure.

Jocelynda Salvador Gloria E HernandezFeiyang MaCyrus W AbrahamsonMatteo PellegriniRobert GoldmanKaren M RidgeM Luisa Iruela-Arispe

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

Through single-cell RNA-sequencing and by tracking closure of the ductus arteriosus in mice, we uncovered the unexpected contribution of vimentin in driving complete closure of the ductus arteriosus through a mechanism that includes deregulation of the Notch signaling pathway.

Keyphrases

single cell
rna seq
signaling pathway
high throughput
gene expression
pi k akt
epithelial mesenchymal transition
cell proliferation
transcription factor
skeletal muscle
metabolic syndrome
heat shock