Heavy Chain Constant Region Usage in Antibodies to Peptidylarginine Deiminase 4 as a Marker of Disease Subsets in Rheumatoid Arthritis.
E Gómez-BañuelosJ ShiH WangMaria I DanilaS L BridgesJon T GilesG P SimsFelipe AndradeErika DarrahPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Anti-PAD4 IgG1, anti-PAD4 IgG3, and anti-PAD4 IgE antibodies identify discrete disease subsets in RA, suggesting that heavy chain usage drives distinct effector mechanisms of anti-PAD4 antibodies in RA.