Diabetes, metabolic comorbidities, and risk of hepatocellular carcinoma: Results from two prospective cohort studies.

Tracey G SimonLindsay Y KingDawn Q ChongLong H NguyenYanan MaTrang VoPhamEdward L GiovannucciCharles S FuchsJeffrey A MeyerhardtKathleen E CoreyHamed KhaliliRaymond T ChungXuehong ZhangAndrew T Chan

Published in: Hepatology (Baltimore, Md.) (2018)

T2D is independently associated with increased risk for HCC in two prospective cohorts of U.S. men and women. This risk is enhanced with prolonged diabetes duration and with comorbid metabolic conditions, suggesting the importance of insulin resistance in the pathogenesis of HCC. (Hepatology 2018;67:1797-1806).

Keyphrases

type diabetes
cardiovascular disease
glycemic control
case control
metabolic syndrome
adipose tissue